Diffuse plane normolipemic xanthomatosis associated with monoclonal gammopathy.

Abstract

Case Report A 65-year-old woman presented with a 3-year history of welldemarcated, yellow to orange macules and plaques in both axillary regions and on the eyelids ( fig. 1 ). Similar streaky lesions were apparent in the intertriginous abdominal skin folds, in the antecubital fossae and in the lines of the hand ( fig. 1 ). There was no history of hyperlipoproteinemia, and blood analysis revealed no signs of hyperlipidemia. Serum protein electrophoresis and immunofixation showed an IgG monoclonal gammopathy of undetermined significance while there was no evidence of multiple myeloma. A skin biopsy specimen was obtained from a lesion in the right antecubital fossa ( fig. 2 ). Histopathological examination of the hematoxylin-eosin-stained skin biopsy specimen revealed lipid-loaded macrophages (foam cells) that were diffusely spread

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